发明名称 |
Powder-layered oral dosage forms |
摘要 |
An oral dosage form of morphine is formulated by powder-layering an homogeneous mixture of morphine sulfate and hydrous lactose impalpable onto inert beads to obtain a multiparticulate product. A plurality of the powder-layered beads may be administered either in immediate release form or in an extended release form by coating with a hydrophobic material. In addition, multi-particulate oral dosage forms containing therapeutically effective agents containing a plurality of pharmaceutically acceptable inert beads powder-layered with homogeneous mixture of a therapeutically effective agent and hydrous lactose impalpable are also disclosed. A method of preparing the dosage forms as well as a method preparing spheroids containing the homogeneous mixture of therapeutically effective agent and hydrous lactose impalpable are also disclosed.
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申请公布号 |
US6077533(A) |
申请公布日期 |
2000.06.20 |
申请号 |
US19980005864 |
申请日期 |
1998.01.12 |
申请人 |
PURDUE PHARMA L.P. |
发明人 |
OSHLACK, BENJAMIN;PEDI, FRANK |
分类号 |
A61K9/16;A61K9/50;(IPC1-7):A61K9/62 |
主分类号 |
A61K9/16 |
代理机构 |
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