发明名称 |
Treatment of migraine headache |
摘要 |
This invention comprises a non-vasoactive, supra-vasoactive syndrome ("SVS") minimized dosage form for treatment of migraine in a human comprising (i) rapid availability metoclopramide in at least about an effective local gastrointestinal amount; (ii) at least one long acting NSAID such as naproxen sodium in a therapeutically effective amount; (iii) wherein said dosage form is a coordinated dosage form; and, (iv) wherein the dosage form is absent 5HT agonist vasoactive agents, and preparation thereof. Acid-base stable dosage forms are noted. This invention further comprises methods of migraine treatment, and methods for rapid introduction of oral NSAID into the small bowel.
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申请公布号 |
US6077539(A) |
申请公布日期 |
2000.06.20 |
申请号 |
US19970966506 |
申请日期 |
1997.11.10 |
申请人 |
POZEN, INC. |
发明人 |
PLACHETKA, JOHN R.;CHOWHAN, ZAKAUDDIN T. |
分类号 |
A61K9/30;A61K9/20;A61K9/22;A61K9/24;A61K9/46;A61K31/122;A61K31/166;A61K31/19;A61K31/192;A61K31/196;A61K31/407;A61K31/421;A61K31/5415;A61K45/00;A61K47/32;A61K47/38;A61K47/46;A61P25/06;(IPC1-7):A61K9/22;A61K9/26;A61K9/28 |
主分类号 |
A61K9/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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