METHODS AND SYSTEMS USEFUL FOR TRANSFERRING GENES INTO PANCREATIC ISLETS EX VIVO AND INTO THE PANCREAS IN VIVO

摘要

The present invention provides methods for transducing interleukin-4 or other immunoregulatory genes into pancreatic islets by a lentiviral expression vector. The methods include transplantation of the transduced islets as grafts into a subject for protecting against insulinitis associated with diabetes or for treating diabetes in a subject having the disease.