BIOLOGICALLY ACTIVE CARBOXYMETHYLDEXTRAN N-ARYLAMIDES

摘要

The present invention pertains to the field of medicine, more precisely to that of pharmacology, and essentially relates to biologically active synthetic derivatives of dextran. The purpose of this invention is to create new chemical compounds having a high interferon-inducing activity as well as an antiviral action. To this end, this invention involves synthesising new substances that consist of immuno-modulators based on carboxymethyldextran N-arylamides of general formula (I) where Z is COONa or CH. This invention also relates to a general method for producing these substances, to synthesis examples, to results of their identification as well as to data from comparative experiments for determining the immuno-modulating and anti-herpes activity as well as the toxicity. The synthesised substances exhibit a high immuno-modulating efficiency and a low toxicity.