| 摘要 |
<p>The present invention pertains to the field of medicine, more precisely to that of pharmacology, and essentially relates to biologically active synthetic derivatives of pyrimidine which are intended for use as antiviral, immuno-stimulating, anti-chlamydia, anti-tuberculosis, psycho-depressive, analgesic and hepatic protection agents. These compounds can further be used in the treatment of malignant tumors as well as in veterinary medicine. The purpose of this invention is to create new chemical compounds having a high and clearly expressed biological activity. To this end, this invention involves synthesising 2,4-dioxo-5-arylidenimino-1,3-pyrimidines of general formula (I) where R is selected from the group comprising H, OH, alkoxyl, halogen, nitrodialkyl, aryl and 3,4-dioxolano. This invention further relates to a general method an to an example of their synthesis, to a list of 25 synthesised and tested substances, to results of their identification as well as to a report concerning a wide comparative and experimental verification of their biological properties and of their toxicity.</p> |
