发明名称 |
CO-FACTORS FOR TROPHIC FACTORS, AND METHODS OF USE THEREOF |
摘要 |
The present invention is based on the discovery and isolation of a co-factor for trophic factors. It has been discovered that trophic factors require a c o- factor to stimulate and/or potentiate the trophic factor activity and/or specificity. This was clearly identified in low density cells where trophic factors are unable, or at best, at minimal levels, able to proliferate undifferentiated cells without a co-factor. In a particular embodiment of th e present invention, there is provided a composition comprising glycosylated cystatin C (CCg), an FGF co-factor that stimulates proliferation of neural a nd fibroblast associated undifferentiated cells. The N-glycosylation of cystati n C is required for its activity. Moreover, CCg acts in cooperation with basic fibroblast growth factor (FGF-2) to induce neural progenitor cell proliferation.
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申请公布号 |
CA2354378(A1) |
申请公布日期 |
2000.06.15 |
申请号 |
CA19992354378 |
申请日期 |
1999.12.13 |
申请人 |
THE SALK INSTITUTE FOR BIOLOGICAL STUDIES |
发明人 |
GAGE, FRED HARRISON;RAY, JASODHARA;TAUPIN, PHILIPPE J. |
分类号 |
C07K14/81;(IPC1-7):C07K14/81;A61K38/57;G01N33/554;G01N33/53;C07K16/40;A61K38/14;A61K35/12;C12N5/06;C12N5/02;C12Q1/00;C12N5/00;C07K14/00;A61K38/00 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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