SUBSTITUTED THIAZOLES FOR TREATMENT OF HUMAN DISEASES INVOLVING MODULATORS OF P-, L- AND E- SELECTIN

摘要

Compounds of Formula (1) (where at least one of R<1>, R<2> or R<3> contains calcium binding moiety e.g. CO2H etc.) are disclosed. Where R<1> is typically a moiety containing a terminal carboxylic acid group such as cinnamic acid or phenoxy acetic acid, R<2> is typically a hydrophobic moiety such as functionalized alkyl chain or a functionalized aryl group, and R<3> is typically a functionalized aryl group, are within the scope of this invention. These compounds exhibit inhibitory activity against P-, L- and E-selectin and are indicated in the treatment of human diseases involving P-, L- and E-selectin.