| 摘要 |
<p>The present invention is directed to a solid sustained release pharmaceutical tablet for administering to a host, comprising a therapeutically effective amount of a pharmaceutically active ingredient and a sustained release carrier therefor, said sustained release carrier comprising (a) a hydrocolloid selected from the group consisting of xanthan gum, guar gum, and alginic acid or a pharmaceutically acceptable salt thereof, and (b) a cellulose ether, said hydrocolloid and cellulose ether being present in synergistic effective amount to retard release of said pharmaceutically active ingredient, said hydrocolloid being present in amount ranging from about 0.3 % to about 7.0 % by weight of the tablet and said cellulose ether being present in an amount ranging from 3 % to about 20 % of said tablet, and cellulose ether being present in said carrier in amounts equal to or greater than 33 % by weight and said carrier being present in amounts less than 35 % by weight of said tablet.</p> |
