摘要 |
Palladium-substituted Bacteriochlorophyll derivatives of formula (I), wherei n A represents OH, OR1, -O-(CH2)n-Y, -S-(CH2)n-Y, -NH-(CH2)n-Y, -O-(CH2)2-NH2, - O-(CH2)2-OH, -NH-(CH2)n- +N o, X-, -NH-(CH2)2-NH=BOC or -N-(CH2-CH=CH2)2; wherein R1 represents Na+, K+, (Ca2+)0,5, (Mg2+)0,5, Li+, NH4+, +NH3- C(CH2OH)3, +NH3-CH2-(CHOH)4-CH2OH, +NH2(CH3)-CH2-(CHOH)4-CH2OH or +N(Cn'H2n'+1)4; R2 represents H, OH or COOR4, wherein R4 is C1-C12 alkyl or C3- C12 cycloalkyl; R3 represents H, OH or C1-C12 alkyl or alkoxy; n is 1, 2, 3, 4, 5 or 6, Y is -NR'1R'2 or -+NR'1R'2R'3, X- wherein R'1, R'2 and R'3 independently from each other represent -CH3 or -C2H5; X is F, Cl, Br or l, n' is 1, 2, 3 or 4 and their oxidized forms, are useful in the field of photodynamic therapy (PDT). |