发明名称 |
PURIFICATION OF ECHINOCANDIN CYCLOPEPTIDE COMPOUNDS |
摘要 |
A method is described for separating and purifying a wide variety of fermentation cyclopeptide products containing at least one protonatable amin o group (including the deacylated Echinocandin-type compounds) from their fermentation or mixed broths and partially purified process streams by adsorbing the mixture onto a hydrophobic, reversed phase chromatographic med ia and eluting with a continuous linear acetic acid gradient ranging from 0.1 % acetic acid to 10.0 % acetic acid by volume in water. A process for removing tripeptide-aldehyde by-products from the fermentation products by means of a derivatizing agent is also described.
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申请公布号 |
CA2353930(A1) |
申请公布日期 |
2000.06.15 |
申请号 |
CA19992353930 |
申请日期 |
1999.12.08 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
VICENZI, JEFFREY THOMAS;KROEFF, EUGENE PAUL;DOBBINS, JOHN ROBERT |
分类号 |
A61K38/00;A61K38/12;A61P31/10;C07K1/16;C07K1/20;C07K7/56;(IPC1-7):C07K7/56 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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