发明名称 |
Glycoconjugates and methods |
摘要 |
Methods for making the functionalized glycoconjugates include (a) contacting a cell with a first monosaccharide, and (b) incubating the cell under conditions whereby the cell (i) internalizes the first monosaccharide, (ii) biochemically processes the first monosaccharide into a second saccharide, (iii) conjugates the saccharide to a carrier to form a glycoconjugate, and (iv) extracellularly expresses the glycoconjugate to form an extracellular glycoconjugate comprising a selectively reactive functional group. Methods for forming products at a cell further comprise contacting the functional group of the extracellularly expressed glycoconjugate with an agent which selectively reacts with the functional group to form a product. Subject compositions include cyto-compatible monosaccharides comprising a nitrogen or ether linked functional group selectively reactive at a cell surface and compositions and cells comprising such saccharides.
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申请公布号 |
US6075134(A) |
申请公布日期 |
2000.06.13 |
申请号 |
US19970856865 |
申请日期 |
1997.05.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
BERTOZZI, CAROLYN;YAREMA, KEVIN J.;MAHAL, LARA K. |
分类号 |
A61K47/48;A61K49/08;A61K49/10;C07H15/12;C07H15/203;C12N5/06;(IPC1-7):C07H15/00;C07H19/00;A61K39/385 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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