发明名称 |
Formulations for sustained-release of topical anesthetics and methods of making and using same |
摘要 |
The present invention provides, inter alia, formulations useful to ameliorate symptoms associated with mucosal abrasions, specifically those due to dental orthodontic brackets; oral surgery; periodontal surgery or other procedures. For instance, there is a formulation comprising: 65 to 75% microcrystalline wax; 5 to 15% non-ionic polymer; 15 to 25% topical anesthetic; and 1 to 5% surfactant, wherein the ratio of non-ionic polymer to microcrystalline wax is no greater than 0.2. Preferably, for solid topical anesthetics, the particle size is less than the apertures of a 100-mesh screen. However, the topical anesthetic may also be a liquid. Formulations wherein the mixture is a homogeneous matrix is preferred.
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申请公布号 |
US6074674(A) |
申请公布日期 |
2000.06.13 |
申请号 |
US19980119099 |
申请日期 |
1998.07.20 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
JAY, MICHAEL JOSEPH;KLUEMPER, G. THOMAS;KIM, SANG HUN |
分类号 |
A61K9/00;A61K9/20;(IPC1-7):A61K9/50 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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