| 摘要 |
The present invention provides a method for the conjugation of peptide molecules with oligonucleotide molecules by means of accessory molecules attached to the peptide or oligonucleotide molecules performing the Diels Alder reaction. Specifically, either a diene or dienophile moiety is attached to a peptide molecule, with the moiety which is not selected above being attached to an oligonucleotide, this attachement being facilitated by a number of possible ways. The pursuing Diels Alder reaction results in the diene and dienophile groups forming a sic membered cyclohexane ring structure which, due to the attachement of the diene and dienophile with the peptide and oligonucleotide molecules participating molecules in the reaction, serves to form a peptide oligonucleotide hybrid molecule. |
