发明名称 |
Osteoblast and fibroblast antigen and antibodies recognizing it |
摘要 |
Monoclonal antibodies (MAb) are provided which have binding specificity to an antigen expressed on osteogenic and fibroblastic cells (OFA) and are capable of binding to osteogenic and fibroblastic cells at a substantially higher extent as compared to their binding to skin fibroblasts and stromal adipocytes. Also provided is a novel osteogenic and fibroblastic antigen (OFA) which is expressed on osteogenic and fibroblastic cells at a higher level than its expression in skin fibroblasts and stromal adipocytes having a molecular weight of about 80 kD as determined by western blotting or immunoprecipitation. The OFA and anti-OFA-MAbs are useful in the diagnosis and treatment of various hone related conditions.
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申请公布号 |
US6074833(A) |
申请公布日期 |
2000.06.13 |
申请号 |
US19960722931 |
申请日期 |
1996.09.30 |
申请人 |
RAMOT UNIVERSITY AUTHORITY |
发明人 |
WIENTROUB, SHLOMO;BENAYAHU, DAFNA |
分类号 |
C07K16/28;(IPC1-7):G01N33/53;C12N5/12;A61K35/14 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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