PHARMACEUTICALS

摘要

Drugs comprising compounds (I) represented by general formula (1) or salts thereof combined with emetic drugs wherein the ring M is a heterocycle havin g, as the partial structure -X Y~, -N=C~, -CO-N~ or -CS-N~; Ra and Rb are bonde d to each other to form the ring A, or Ra and Rb are the same or different and each represents hydrogen or a substituent of the ring M; the rings A and B a re each an optionally substituted homocycle or heterocycle and at least one of them is an optionally substituted heterocycle; the ring C is an optionally substituted homocycle or heterocycle; the ring Z is an optionally substitute d nitrogen-containing heterocycle; and n is an integer of 1 to 6. The compound s (I) or salts thereof are useful as antiemetic agents. In particular, they ca n rapidly and safely inhibit even at a small dose emesis induced by emetic dru gs.