beta -ALANINE DERIVATIVES AS alpha 4 INTEGRIN INHIBITORS

摘要

Alkanoic acid derivatives of formula (1) are described: Ar<1>(Alk<a>)rL<1>Ar<2>CH(R<1>)C(R<a>)(R<a'>)R wherein Ar<1> is an optionally substituted aromatic or heteroaromatic group; L<1> is a covalent bond or a linker atom or group; Ar<2> is an optionally substituted phenylene or nitrogen-containing six-membered heteroarylene group; R is a carboxylic acid (-CO2H) or a derivative thereof; and the salts, solvates, hydrates and N-oxides thereof. The compounds are able to inhibit the binding of alpha 4 integrins to their ligands and are of use in the prophylaxis and treatment of immune or inflammatory disorders.