| 摘要 |
<p>The invention relates to 4'-substituted-4',5'-dihydropsoralen compounds of formula (V). In the formula R is hydrogen, a halogen, CN or an acyl group; T is a halogen, CN, a carboalkoxy group NR?1R2, or (N+R1R2R3)X-, R1 and R2¿ are independently a C¿1?-C6 alkyl, or R?1 and R2¿ together with the nitrogen form a 5-8 member heterocyclic ring, or when T is (N?+R1R2R3)X-, R1 and R2¿ together with the nitrogen form a 5-8 member heterocyclic ring or heterocyclic aromatic ring; R3 is hydroge, a C¿1?-C12 alkyl, or, when R?1 and R2¿ together with the nitrogen form a heterocyclic aromatic ring, R3 is a double bond within the heterocyclic aromatic ring; X is a halide. In another embodiment, the invention relates to processes for preparing 4'-substituted-4',5'-dihydropsoralen compounds described above. The compounds of the invention have beneficial pharmaceutical properties and can be used alone or in pharmaceutical compositions used to treat a proliferative skin disorder and to treat microbial infections in a mammal by administering to the mammal an effective amount of a compound of the invention and then irradiating the mammal with ultraviolet light.</p> |
