| 摘要 |
<p>The present invention relates to an animal model for inducing, producing and propagating papillomavirus and for evaluating candidate therapeutic agents against papillomavirus. The animal model comprises an immuno-deficient animal recipient onto which is grafted excised skin from a xenogeneic donor animal that is free from apparent PV infection and is a host to a host-specific papillomavirus. The grafted skin on the recipient animal supports the propagation of its host-specific papillomavirus. The invention particularly relates to, a recipient animal being a xenograft animal, capable of being a host for propagating a host specific papillomavirus and a means for producing infectious papillomavirus suspension. The invention further relates to the use of the xenograft animal model for evaluating potential therapeutic agents against papillomavirus infection.</p> |
