发明名称 |
STIMULATION OF T CELLS AGAINST SELF ANTIGENS USING CTLA-4 BLOCKING AGENTS |
摘要 |
Stimulation of T cells to respond to self antigens is achieved through a blockade of CTLA-4 signaling. CTLA-4 blocking agents are combined with antigen preparations, either alone or with additional immune response stimulating agents, in costimulation strategies to break immune tolerance and stimulate an enhanced T-cell response against self antigens. This enhanced response is useful for the treatment of non-immunogenic and poorly-immunogenic tumors, as well as other medical conditions requiring selective tissue ablation.
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申请公布号 |
WO0032231(A1) |
申请公布日期 |
2000.06.08 |
申请号 |
WO1999US28739 |
申请日期 |
1999.12.03 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
ALLISON, JAMES, P.;HURWITZ, ARTHUR, A.;VANELSAS, ANDREA |
分类号 |
A61K45/00;A61K38/46;A61K38/51;A61K39/00;A61K39/395;A61P35/00;A61P37/04;C07K16/28;(IPC1-7):A61K39/395 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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地址 |
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