CONTROLLED RELEASE FORMULATION COMPRISING GNRH-II

摘要

A pharmaceutical formulation for the controlled release of a therapeutic peptide or a salt thereof, which peptide has the sequence pyroGlu-His-Trp-Ser-Xaa<1>-Gly-Xaa<2>-Xaa<3>-Pro-Gly-NH2 wherein Xaa<1> is His or Tyr, Xaa<2> is Trp or Leu, and Xaa<3> is Tyr or Arg, provided that when Xaa<1> is Tyr and Xaa<2> is Leu, then Xaa<3> is not Arg, and which formulation further comprises a pharmaceutically acceptable biodegradable polymer. The formulation can be used for treating bone and prostate disorders.