发明名称 |
A METHOD FOR ENHANCING PROTECTIVE CELLULAR RESPONSES TO GENOTOXIC STRESS IN SKIN |
摘要 |
The present invention is directed to methods of using pro-NAD agents capable of enhancing the dermal and epidermal skin cell NAD content. These pro-NAD agents may be administered topically, orally, or parenterally to enhance DNA repair and other protective responses to DNA damage. The invention further relates to pharmaceutical compositions comprising pro-NAD agents that effectively elevate intracellular NAD content. Finally, the invention relates to the method of using the pro-NAD agents to treat disorders such a s sunburn and other skin deterioration that results from DNA damage in skin cells. |
申请公布号 |
WO0032179(A2) |
申请公布日期 |
2000.06.08 |
申请号 |
WO1999US28446 |
申请日期 |
1999.12.01 |
申请人 |
UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION |
发明人 |
JACOBSON, ELAINE, L.;JACOBSON, MYRON, K. |
分类号 |
A01N43/40;A61K8/49;A61K8/67;A61K9/20;A61K31/00;A61K31/44;A61K31/445;A61K31/455;A61K31/655;A61P17/00;A61Q19/00;H04N5/232;H04N5/247;H04N5/268;(IPC1-7):A61K31/00 |
主分类号 |
A01N43/40 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|