| 摘要 |
The present invention relates to a D.melanogaster insulin-like gene and methods for identifying insulin-like genes. The methods provide nucleotide sequences of a D.melanogaster insulin-like gene, amino acid sequences of its encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a D.melanogaster insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out). Still further, methods to identify a D.melanogaster gene that modifies the function of, and/or functions in a signaling pathway with an insulin-like gene are provided. The invention further provides uses of Drosophila insulin-like nucleic acids and proteins, e.g., as media additives, and as pesticides.
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