Controlled release pharmaceutical formulation

摘要

A pharmaceutical formulation for the controlled release of a therapeutic peptide or a salt thereof, which peptide has the sequence

pyroGlu-His-Trp-Ser-Xaa1-Gly-Xaa2-Xaa3-Pro-Gly-NH2

wherein Xaa1 is His or Tyr,
```Xaa2 is Trp or Leu, and
```Xaa3 is Tyr or Arg,
provided that when Xaa1 is Tyr and Xaa2 is Leu, then Xaa3 is not Arg,
and which formulation further comprises a pharmaceutically acceptable biodegradable polymer preferably a co-polymer of glycolic and lactic acids. The formulation can be used for treating bone and prostate disorders.