Spray dispenser for opioid antagonists

摘要

A spray applicator (1) is to administer an opioid antagonist selected from naloxone and/or naltrexone. The applicator is capable of delivering single or multiple doses of the antagonist through a projecting delivery portion (5) which is shaped or dimensioned for introduction into the nose or mouth. A pharmaceutical composition for nasal or oral administration is also disclosed which comprises an opioid antagonist, such as naloxone and/or naltrexone, and which comprises a water-susceptible solid carrier admixed with the opioid antagonist. The composition may also comprise a hydrophilic polymer which is applied as a coating to the mixture of the solid carrier and the opioid antagonist.