发明名称 |
Coxsackie virus as a vector for delivery of anti-inflammatory cytokines |
摘要 |
The present invention is drawn to the use of artificially attenuated Coxsackievirus B3 cardiotropic virus vectors as efficient gene transfer vectors to deliver immunomodulatory proteins and/or antigenic epitopes in transient infections to aid in preventing, ameliorating, and/or ablating infectious viral heart disease and reducing, or ablating entirely, heart transplant rejection. Additionally, other organs or tissues may be targeted with specific picornaviruses. An attenuated CVB3 viral vector able to express a cytokine is provided. This cytokine-expressing viral vector is able to deliver the cytokine to a target tissue and reduce disease symptoms
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申请公布号 |
US6071742(A) |
申请公布日期 |
2000.06.06 |
申请号 |
US19970812121 |
申请日期 |
1997.03.05 |
申请人 |
BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA |
发明人 |
TRACY, STEVEN M.;CHAPMAN, NORA M.;KOLBECK, PETER;MALONE, JAMES |
分类号 |
C12N15/09;A61K38/00;A61K38/19;A61K38/20;A61K39/00;A61K39/12;A61K39/125;A61K39/21;A61K48/00;A61P9/00;A61P29/00;A61P31/12;A61P37/06;C07K14/54;C07K16/00;C12N7/00;C12N15/19;C12N15/86;(IPC1-7):C12N15/86 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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