Procedure for synthesis of N-(2(((5-((dialkilamino) methyl)-2- furanyl) methyl)thyo) ethyl)-N'- alkyl-2-nitro1,1 alkenediamines and their hydrochlorides

摘要

This invention is related to the procedure for obtaining of the therapeutically active N-[2[[[5-[(dialkylamino methyl]-2-furanyl] methyl] thio] ethyl]-N'-alky-2-nitro1,1 alkenediamines) of formula (I) and their hydrochlorides of formula (II), where R1, R2 and R3 are alkyl groups (C1-C4), and X is nitro-alkenic group by reaction of 2[[[5-[(dimethylamino-methyl-2-furanyl]methyl]thio]-ethanamine-hydrochloride) and N-methyl-1(methylthio-2-nitroethenamine) in the aqueous environment at the mild temperature.