| 摘要 |
1,050,373. Sulphonylisothiocyanates. FARBENFABRIKEN BAYER A.G. May 26, 1964 [May 28, 1963], No. 21733/64. Heading C2C. The invention comprises sulphonyl-isothiocyanates of the formula wherein R represents an alkyl, cycloalkyl, aralkyl, aromatic, which may be substituted or bear an additional sulphonyl isothiocyanate group, or a heterocyclic radical. They may be obtained by reacting sulphonyl iminodithiocarbonates with acid halides. This reaction may be carried out in organic solvents such as chlorinated or unchlorinated hydrocarbons and at temperatures from about - 10‹ C. to 120‹ C. Suitable acid halides are COOl 2 , CSCl 2 , (COCl) 2 , SCl 2 , S 2 Cl 2 , SOCl 2 , SO 2 Cl 2 , PCl 3 , POCl 3 , PCl 5 , PBr 5 , CoBr 2 and ester chlorides of carbonic acid. Suitable sulphonyl iminodithiocarbonates include the metal salts of toluene-, benzene-, methane-, ethane-, #-toluene-, dimethylamino-, propane di-, furan-2-, thiophene-2-, benzthiazole-, pyrazine-, and pyridine-4-sulphonyl iminodithiocarbonate. In one of the examples a dimeric sulphonyl isothiocyanate of the formula is first formed which dissociates to the monomeric 3-chlorobenzene-sulphonyl isothiocyanate on heating. The compounds are useful as intermediate products in the preparation of pharmaceutical compounds and dyestuffs. The metal iminodithiocarbonates may be prepared from sulphonamides and carbon disulphide in the presence of strong bases. |
