FUCOSYLTRANSFERASES, POLYNUCLEOTIDES ENCODING FUCOSYLTRANSFERASES, AND TRANSGENIC MAMMALS INCORPORATING SAME

摘要

This invention is biological in nature and relates to the synthesis, structure and biological activities of novel alpha -1,2 and alpha -1,3 fucosyltransferases from Caenorhabditis elegans ("C.elegans"). The present invention also contemplates a transgenic non-human eukaryotic mammal whose germ cells and somatic cells incorporate cDNA sequences encoding one or more of the novel alpha -1,2 and alpha -1,3 fucosyltransferases from C.elegans, introduced into the non-human eukaryotic mammal, or an ancestor of the non-human eukaryotic mammal, at an embryonic stage.