INHIBITORS OF PRODUCTION AND/OR SECRETION OF AMYLOID-.BETA. PROTEIN

摘要

Compounds represented by general formula (I), salts thereof or prodrugs of t he same which exhibit an excellent effect of inhibiting .beta.-amyloid protein production/secretion, wherein Ar represents an aromatic group; X and Y represent each a divalent group selected from among -O-, -S-, -CO-, -SO-, -S O2- , -NR8-, -CONR8-, -SO2NR8- and -COO- (wherein R8 represents H, hydrocarbyl o r acyl), or divalent aliphatic C1-6 hydrocarbyl optionally containing one or t wo of these divalent groups; R1 and R2 represent each H or C1-6 alkyl, or R1 an d R2 may form together with the nitrogen atom adjacent thereto a nitrogen- containing heterocycle; and the ring A represents a monocyclic aromatic ring .