摘要 |
This invention provides smooth muscle cell proliferation inhibitors of formu la (I) having a structure wherein Y is C or N; where n is 0 - 3; X is (A) where in R1, and R2 are each independently, hydrogen, alkyl of 1 to 6 carbon atoms, halo, acetyl, phenyl, CF3, CN, OH, NO2, NH2, alkoxy of 1 to 6 carbon atoms, or alkoxynitrile of 1 to 6 carbon atoms; R3 is hydrogen, acylamide of 2 to 6 carbon atoms or alkoxy of 1 to 6 carbon atoms; R4, R5, R6, R7 and R8 are eac h, independently, hydrogen, acyl of 1 to 6 carbon atoms, benzyl substituted wit h R1, and R2; or benzoyl substituted with R1 and R2; R9 and R10 are each, independently, acyl of 1 to 6 carbon atoms, or the R9 and R10 groups on the 4' and 6' positions of the maltose may be taken together to form a cyclic aceta l which may be substituted with alkyl of 1 to 6 carbon atoms, two alkyl groups each having 1 to 6 carbon atoms, pyridine substituted with R1, phenyl substituted with R1, benzyl substituted with R1, 2-phenylethyl substituted with R1, or 3-phenylpropyl substituted with R1; or a pharmaceutically acceptable salt thereof.
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