N-[4-(3-CHLORO-4-FLUORO-PHENYLAMINO)-7-(3-MORPHOLIN-4-YL-PROPOXY)-QUINAZOLIN-6-YL]-ACRYLAMIDE, AN IRREVERSIBLE INHIBITOR OF TYROSINE KINASES

摘要

The present invention provides the compound N-[4-(3-chloro -4-fluoro- phenylamino) -7-(3-morpholin -4-yl-propoxy) -quinazolin-6- yl]-acrylamide th at is an irreversible inhibitor of tyrosine kinases. Also provided is a method of treating cancer, restenosis, atherosclerosis, endometriosis, and psoriasis using the compound N-[4-(3-chloro -4-fluoro-phenylamino) -7-(3-morpholin -4- yl- propoxy) -quinazolin -6-yl]-acrylamide, and a pharmaceutical composition tha t contains the compound N-[4-(3-chloro -4-fluoro-phenylamino) -7-(3-morpholin -4- yl-propoxy) -quinazolin-6-yl] -acrylamide.