| 摘要 |
<p>The present invention provides a process for preparing a high yield of purified clarithromycin having broad antimicrobial activity as a macrolide antibiotic agent by using 1,3-benzodithiol-2-ylium tetrafluoroborate (BDFT), which can easily be synthesized from anthranilic acid and used as a protecting group for oxime. In addition, the present invention also provides a process for preparing clarithromycin from 1,3-benzodithiol-2-sulfonic acid group that forms clarithromycin salt which precipitates into crystals in reaction solution thereof, and purifying clarithromycin including a significantly simplified purification step.</p> |
