Antagonists synthetic peptides which are obtained from TGF.beta.1 or from it s receptors in the organism. It is possible to use either the peptides themselves or the genic sequences which code them and the recombinant system s which express them for the fabrication of compositions used in the treatment of hepatic diseases and more particularly in cases of fibrosis. These compositions may optionally include mimotopes of said active peptides.</SDOA B>
申请公布号
CA2352537(A1)
申请公布日期
2000.06.02
申请号
CA19992352537
申请日期
1999.11.23
申请人
INSTITUTO CIENTIFICO Y TECNOLOGICO DE NAVARRA, S.A.
发明人
LASARTE SAGASTIBELZA, JUAN JOSE;BORRAS CUESTA, FRANCISCO;PRIETO VALTUENA, JESUS;EZQUERRO SAENZ, IGNACIO JOSE