USE OF ACTIVATED TRAP FOR SCREENING FOR SPECIFIC INHIBITOR OF TRAP AND METHOD FOR AIDING IN THE IDENTIFICATION OF A COMPOUND FOR USE IN THE TREATMENT OF DISEASES OR DEGENERATIVE CONDITIONS RESULTING IN INCREASED BONE RESORPTION

摘要

The invention relates to the use of activated TRAP (tartrate-resistant and purple acid phosphatases) for screening for specific inhibitor of TRAP activity useful in the treatment of diseases or degenerative conditions resulting in increased bone resorption, such as tissue damages, bone metabolic disorders, osteoporosis. TRAP can be activated by proteolytic activation of TRAP e.g. by cleaving with a protease, papain-like enzyme.