发明名称 |
GENE DELIVERY VECTORS PROVIDED WITH A TISSUE TROPISM FOR SMOOTH MUSCLE CELLS, AND/OR ENDOTHELIAL CELLS |
摘要 |
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for smooth muscle cells and/or endothelial cells. In one aspect said nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue thereof. Preferably said virus capsid is an adnovirus capsid. Preferably said adenovirus is a subgroup B adenovirus, preferably adenovirus 16. Preferably said tissue tropism is provided by at least a tissue tropism determining part of an adenovirus fiber protein or a functional derivative and/or analogue thereof. The invention further presents methods for the treatment of diseases, preferably cardiovascular diseases.
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申请公布号 |
CA2318492(A1) |
申请公布日期 |
2000.06.02 |
申请号 |
CA19992318492 |
申请日期 |
1999.11.22 |
申请人 |
INTROGENE B.V. |
发明人 |
BOUT, ABRAHAM;HAVENGA, MENZO JANS EMCO;VOGELS, RONALD |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P9/00;C07K14/075;C12N5/10;C12N15/861;C12P21/02;C12R1/92;(IPC1-7):C12N15/861;C12N15/34;C12N15/62 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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