发明名称 |
PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES |
摘要 |
<p>A group of 2-amino-3-aroyl-benzo[ beta ]thiophenes are prepared by preparing an alpha -hydroxy thioacetamide by silyl mediated condensation of an aldehyde with an anion of dialkylamino thioformamide, cyclizing the alpha -hydroxy thioamide, and subsequently acylating the benzo[ beta ]thiophene to yield the 2-amino-3-aryl derivative. These compounds may be treated with suitable phenyl Grignard reagents, and after deprotection, yield 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[ beta ]thiophene.</p> |
申请公布号 |
GR3032409(T3) |
申请公布日期 |
2000.05.31 |
申请号 |
GR20000400106T |
申请日期 |
2000.01.19 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
GODFREY, ALEXANDER, GLENN |
分类号 |
C07C327/44;C07D333/56;C07D333/66;(IPC1-7):C07C327/44 |
主分类号 |
C07C327/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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