| 摘要 |
<p>A method for preparing an effervescent granulate from a mixture comprising at least one acid ingredient and at least one basic ingredient which are suitable for forming an effervescent system, in which the said mixture is granulated with water in a fluid air bed granulator at a temperature which is predetermined as a function of the composition to be granulated, while keeping the said temperature essentially constant. A granulate comprising citric acid and at least one basic ingredient which is suitable for forming an effervescent system with the citric acid, in which the said citric acid is partly in powder form and partly in crystalline form, and pharmaceutical forms containing it.</p> |
