| 摘要 |
PCT No. PCT/GB97/00169 Sec. 371 Date Jul. 27, 1998 Sec. 102(e) Date Jul. 27, 1998 PCT Filed Jan. 21, 1997 PCT Pub. No. WO97/27188 PCT Pub. Date Jul. 31, 1997The invention concerns a compound of formula (I) wherein: R1 is of the formula -NHC(=O)(1-4C)alkyl, -NHS(O)n(1-4C)alkyl wherein n is 0, 1 or 2 or R1 is hydroxy; R2 and R3 are independently hydrogen or fluoro; R4 is hydrogen, methyl, ethyl or oxo; R5 is hydrogen, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl or of the formula R6(CH2)m- wherein either m is 1-4 and R6 is, for example, trifluoromethyl, difluoromethyl, fluoromethyl, (1-4C)alkoxy, (1-4C)alkyl S(O)p- wherein p is 0, 1 or 2, (1-6C)alkanoyloxy, di-(+E,uns N+EE -(1-4C)alkyl)amino, +E,uns N+EE -((1-4C)alkyl)(1-4C)alkanoylamino, cyano, carboxy, (1-4C)alkoxycarbonyl, carbamoyl, di-(+E,uns N+EE -(1-4C)alkyl)carbamoyl, +E,uns N+EE -((1-4C)alkyl)(1-4C)alkanesulphonamido, +E,uns N+EE 1-((1-4C)alkyl)-di-(+E,uns N+EE 3-(1-4C)alkyl)ureido, or of the formula -OC(=O)NR7(R8) or -N(R9)SO2NR7(R8) wherein R7 and R8 are independently hydrogen or (1-4C)alkyl and R9 is (1-4C)alkyl; or m is 2-4 and R6 is, for example, hydroxy, (1-4C)alkanoylamino, amino, (1-4C)alkylamino, (1-4C)alkanesulphonamido, ureido, di-(+E,uns N+EE 3-(1-4C)alkyl)ureido or of the formula -NHSO2NR7(R8); and pharmaceutically-acceptable salts thereof; processes for their preparation; pharmaceutical compositions containing them and their use as antibacterial agents.
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