发明名称 |
Methods of making nanocrystalline formulations of human immunodeficiency virus (HIV) protease inhibitors using cellulosic surface stabilizers |
摘要 |
The present invention describes formulations of nanoparticulate HIV protease inhibitors comprising a cellulosic surface stabilizer. The nanoparticulate formulations have an increased rate of dissolution in vitro, an increased rate of absorption in vivo, a decreased fed/fasted ratio variability, and a decreased variability in absorption. The present invention is also directed to methods of making the novel formulations. In particular, nanoparticulate formulations of HIV type 1 (HIV-1) and type 2 (HV-2) protease inhibitors are described.
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申请公布号 |
US6068858(A) |
申请公布日期 |
2000.05.30 |
申请号 |
US19990225493 |
申请日期 |
1999.01.06 |
申请人 |
ELAN PHARMA INTERNATIONAL LIMITED |
发明人 |
LIVERSIDGE, GARY G.;ENGERS, DAVID A.;ROBERTS, MARY E.;RUDDY, STEPHEN B.;WONG, SUI-MING;XU, SHUQIAN |
分类号 |
A61K9/14;A61K9/20;A61K9/51;A61K31/192;A61K31/366;A61K31/427;A61K31/472;A61K31/4725;A61K31/551;A61K31/635;A61K38/55;(IPC1-7):A61K9/14 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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