| 摘要 |
The invention relates to compounds of formula (I) which have inhibitory effects on farnesyl transferase. Some of these compounds present in vitro inhibition of farnesyl transferase at concentrations < 1 mu M. The compounds provided for in the invention have the general formula (I), in which n is between 0 and 3; R<1>, R<2> are H, alkyl, aryl, heteroaryl, acyl; R<3> is H, halogen, alkyl, aryl, heteroaryl, arylalkyl, acyl, CN, NO2, R<4>-X-; R<4> is H, alkyl, aryl, heteroaryl, aralkyl, acyl; X is NH, O, S, SO2, NHSO2, OSO2; and A, B, C are organic rests. |
