A process for the alkylation of alkyl- or benzylcyanogen derivatives in the presence of trialkylamines or -phosphines

摘要

A process for the preparation of the compounds of the formula 1 wherein: R1 is (C1-C20)-alkyl or mono, di or trisubstituted (C1-C20)-alkyl, R2 is (C1-C20)-alkyl, mono, di or trisubstituted (C1-C20)-alkyl, phenyl or mono, di or trisubstituted phenyl and R3 is phenyl or mono, di or trisubstituted phenyl. The process involves reacting benzylcyanogen derivatives of the formula II wherein: R3 is phenyl or mono, di or trisubstituted phenyl, R4 is H or (C1-C20)-alkyl, mono, di or trisubstituted (C1-C20)-alkyl, phenyl or mono, di or trisubstituted phenyl with compounds of the formula V and/or formula VI wherein: R7, R8, R9, R10, R11, and R12 can be the same or different and are selected from (C1-C30)-alkyl or phenyl. The products produced by this process can be used for the preparation of antiallergically effective medicaments such as 4-[4[-4-(hydroxydiphenyl)-1-piperidinyl]-1-hydroxybutyl]-a,a-dimethylphenylacetic acid.