Polyvalent polymers comprising one or more fucoside monomers for the treatment of rotaviral infections

摘要

The disclosure includes polymerizable monomers comprising a fucoside moiety as pictured above. In one embodiment, the monomer has a polymerizable functional group, such as an olefinic bond, to which the fucoside moiety is attached by a spacer group, for example, an alkylene group, or an alkylene group wherein one or more carbon atoms are substituted by heteroatoms, such as oxygen, nitrogen or sulfur atoms. The disclosure also includes polymers comprising one or more fucoside moieties, such as pendant fucoside moieties, which can inhibit or prevent rotavirus infection in a mammal. Such a polymer can comprise, for example, a monomer of the present disclosure. The polymer can be a homopolymer or a copolymer, and can have, for example, a polyacrylamide, polyacrylate or polystyrene backbone. The present disclosure also comprises a method for manufacturing medicaments for treating a rotavirus infection in a mammal, for example, a human, said medicament comprising a therapeutically effective amount of a polymer comprising one or more glycoside moieties, such as pendant glycoside moieties to be administered to said mammal. The glycoside moieties can be, for example, fucoside moieties or sialic acid moieties. In one embodiment, the polymer is a copolymer comprising a glycoside-bearing monomer and a hydrophobic monomer. In another embodiment, the polymer to be administered comprises two or more different glycoside-bearing monomers.