Antioxidant nitrone compounds for neurodegenerative disorders

摘要

Nitrone compounds shown as Formula (I) are described, as well as their preparation and pharmaceutical compositions containing them. These compounds are antioxidants, traps for reactive oxygenated species, which are capable of combating "oxidation stress" in the cerebral region. The compounds are capable of combating cognitive disorders associated with cerebral aging or neurodegenerative disorders, and also combating neurone death associated not only with acute neurodegenerative disorders such as, for example, ischaemia and epilepsy, but also with progressive neurodegenerative disorders, such as, for example Alzheimer's disease, Pick's disease or neurodegeneracies of the basal ganglia. Nitrone compounds as described by Formula (I); Wherein: W represents an aryl group, aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, a heteroaryl group or a heteroaryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, R1 represents a linear or branched (C1-C6)alkyl, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, an aryl group, a cycloalkyl group, an aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, or a cycloalkyl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, R2 represents a H atom, a linear or branched (C1-C6)alkyl group, an aryl group, an aryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, a cycloalkyl group, a cycloalkyl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, a heterocycloalkyl group, a heterocycloalkyl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, a heteroaryl group, a heteroaryl-(C1-C6)alkyl group in which the alkyl moiety may be linear or branched, a linear or branched (C1-C6)acyl group, a linear or branched (C1-C6)alkylsulphonyl group in which the alkyl moiety may be linear or branched, or a linear or branched (C2-C6)alkenyl group, Their isomers, and also additions salt thereof with a pharmaceutical acceptable acid or base.