摘要 |
Compounds of the above formula in which: X, Y and Z are oxygen; R1 represents a group W-V: W is a valence dash or a straight-chained or branched C1-C8 alkyl or a C2-C8 alkenyl group which is optionally once or several times substituted, V is an optionally substituted monocycle or bicycle which can contain one or several heteroatoms, or W-V is a C1-C20 alkyl group which can be interrupted by heteroatoms or one or several carbon atoms are optionally substituted; R2 and R3 represent hydrogen; R4 and R5 denote independently of each other for A-D, wherein A represents a dash alkyl, alkenyl, acyl, alkylsulfonyl, sulfonyl, alkylaminocarbonyl, aminocarbonyl, alkoxycarbonyl, oxy-carbonyl, alkylaminothiocarbonyl, aminothio-carbonyl which is optionally once or several times substituted; D represents a hydrogen, monocycle or bicycle, the monocycle or bicycle is optionally once or several times interrupted by heteroatoms and the monocycle or bicycle is once or several times substituted, or R4 and R5 together with the adjacent N atom form a ring. Also claimed are the pharmacologically acceptable salts and prodrugs thereof, their optically active forms and the process for their production. In addition, the pharmaceutical agents comprising these compounds which are capable of matrix metalloprotease-inhibitory action are disclosed.
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