ANTIHERPES COMPOUNDS

摘要

Disclosed herein are compounds of the general formula X-Aryl-Y-Z wherein X is a five or six-membered aromatic heterocycle attached to an Aryl group, for example a phenyl group; Y is absent or a bridging group, for example NHC(O)CH2; and Z is a terminal group, for example NHC(O)OC(CH3)3 or (I). The compounds inhibit the herpes helicase-primase enzyme, rendering the compounds useful as antiviral agents. Also disclosed are pharmaceutical compositions comprising the compounds, as well as methods of preparing and using the compounds.