NOVEL MEMBRANE OR MATRIX FOR CONTROLLING DRUG PERMEATION

摘要

The invention relates to a membrane or matrix, made of a siloxane-based elastomer, and intended for controlling the permeation of drugs, wherein said elastomer comprises 3,3,3,-trifluoropropyl groups attached to the Si-atoms of the siloxane units. The invention relates also to a method for the preparation of a siloxane-based elastomer comprising 3,3,3,-trifluoropropyl substituents, wherein said elastomer is intended for controlling the permeation of drugs. In the method either i) a 3,3,3,-trifluoropropyl-substituted vinyl-functional polysiloxane component and a silicon hydride-functional cross-linking agent are cross-linked in the presence of a catalyst, or ii) a 3,3,3,-trifluoropropyl-substituted polysiloxane component is cross-linked in the presence of a peroxide catalyst.