| 摘要 |
<p>The present invention relates to the field of proteomics. More specifically, the present invention describes methods and apparatus for the isolation, characterizing, screening, recombining and interacting of biological molecules such as proteins, peptides, nucleic acids and ligands so as to analyze various biological activities of these molecules individually or on a cellular scale. Moreover, the invention relates to the positional mapping of isolated biological molecules in multiple solution-base separation means so as to provide a unique set of identifying characteristics for each biological molecule in a system. The invention further relates to the utilization of this information for the simultaneous screening, selection and enrichment of interactive ligands, substrates or other interactive molecules in many thousands of parallel ligand-target, substrate-enzyme or other biological interactions. The invention further relates to identification and display of the target molecules or interactive molecules for subsequent analysis. The present invention is valuable in the screening and study of potential small therapeutic molecules and their interactions in various cell types of choice.</p> |
