发明名称 |
Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
摘要 |
The invention provides a nucleic acid delivery vehicle with or having been provided with at least a tissue tropism for smooth muscle cells and/or endothelial cells. In one aspect said nucleic acid delivery vehicle is a virus capsid or a functional part, derivative and/or analogue thereof. Preferably said virus capsid is an adnovirus capsid. Preferably said adenovirus is a subgroup B adenovirus, preferably adenovirus 16. Preferably said tissue tropism is provided by at least a tissue tropism determining part of an adenovirus fiber protein or a functional derivative and/or analogue thereof. The invention further presents methods for the treatment of diseases, preferably cardiovascular diseases. |
申请公布号 |
AU5960099(A) |
申请公布日期 |
2000.05.25 |
申请号 |
AU19990059600 |
申请日期 |
1999.11.22 |
申请人 |
INTROGENE B.V. |
发明人 |
RONALD VOGELS;MENZO JANS EMCO HAVENGA;ABRAHAM BOUT |
分类号 |
C12N15/09;A61K35/76;A61K38/00;A61K48/00;A61P9/00;C07K14/075;C12N5/10;C12N15/861;C12P21/02;C12R1/92 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|