| 摘要 |
<p>A nozzle (302) comprised of a thin, flexible membrane material having a plurality of pores is disclosed. In one embodiment, the pores have an unflex ed exit aperture diameter in the range of about 0.5 microns to about 2 microns (preferably about 1 micron), and are positioned substantially uniformly in t he material, preferably about 50 microns apart. The nozzle (302) preferably has a conical or trumpet shaped cross section. In another aspect of the invention, the exit aperture of the nozzle (302) is surrounded by an elevated area (81) protruding above the substantially planar exit side of the membrane in order to prevent intrusion of liquid back into the nozzle (302). The nozzle (302) can be used to form an aerosol containing a pharmaceutical composition from the exit side (38) of the nozzle (302) upon forcible application of the composition to the entrance side of the nozzle (302). This aerosol can be us ed to administer the pharmaceutical composition, for example, to the eye or to a selected portion of the respiratory tract. The nozzle (302) is preferably a component of a container (1) which holds a formulation (5) of drug.</p> |
