| 摘要 |
PURPOSE: An inexpensive, scalable, direct route to esters of (S)-3,4-O-isopropylidene-3,4-dihydroxybutyric acid and (S)-3-hydroxybutyrolactone from a carbohydrate source is provided. CONSTITUTION: The process for the preparation of protected esters of(s)-3,4-dihydroxybutyric acid comprises the following steps of (a) treating a carbohydrate substrate in a solvent with hydrogen peroxide in the presence of a base and subsequent acidification with an acid to afford a mixture comprising a compound of formula(IV) and glycolic acid; (b) removing the solvent to convert the compound of formula(IV) to the compound of formula(II); (c) treating the mixture containing the compound of formula(II) with an alcohol of formula(VI); and treating the mixture containing a compound of formula(V) with a compound of formula(III), to obtain a compound of formula(I).
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